Pryor also commented on the matter on the campaign trail in Northwest Arkansas on Wednesday.
"My faith is very personal to me and it's a deep seeded belief system I have. And for him to say that. I'm just very disappointed he's taking his campaign that direction," Pryor said.
At the same event, Cotton responded to the controversy.
"I simply said that by virtue of his vote for obamacare, Mark Pryor is infringing on the religious freedom of other Christians or anyone of all faiths who objects to practices like abortion," Cotton said.
Cotton campaign spokesperson David Ray sent a statement to Channel 7 News from Cotton in response to the backlash."Senator Pryor is a man of faith and practices it with commendable openness, which I respect, but I wish he would respect Arkansans' right to practice our faith. Instead, Senator Pryor and President Obama still defend Obamacare even after the Supreme Court said it violated freedom of religion. Senator Pryor supports taxpayer-funded abortion and late-term abortion and would force Christians to pay for abortions despite their deeply held religious beliefs. That's a real attack on faith," Cotton said.The Cotton campaign would not answer if Cotton planned to make a formal apology. Last year, Pryor's campaign was attacked by the National Republican Senatorial Committee for his ad "North Star" in which Pryor touted his faith in the Bible. The Cotton campaign denounced the NRSC attack, calling the attack "bizarre and offensive."